10 reasons you might be gaining weight that have nothing to do with your diet

Side effects of your medications could be causing you to gain weight.

Medication, especially anti-depressants, can have a side effect of weight gain.
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Certain medications, particularly antidepressants, can cause you to gain weight as a side effect of the drug.

“[SSRI antidepressants] have weight-gain potential when taken for more than a couple of months,” Dr. Lofton said. “That’s a really common [reason for weight gain].”

“You could just do an online search and see if weight gain is one of the side effects of your medication. That’s readily available information online,” she added. “Also, talk to your doctor. If the medication you are on does have weight-gain potential, there are likely some alternatives in similar classes that might be better for you.”

You might have a hormone imbalance that makes you gain weight.

Hormone imbalance can cause weight gain.
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Your hormones are chemicals that control most of your bodily functions. So, if you’re gaining weight without any obvious explanation, it could be a sign you have a hormone imbalance.

According to StyleCraze, the hormones that are most likely to cause weight gain include: thyroid, insulin, leptin, ghrelin, estrogen, cortisol, testosterone, progesterone, melatonin, and glucocorticoids.

Other medical conditions can also cause you to gain weight.

PCOS can cause weight gain due to reproductive hormone imbalance.
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Dr. Lofton said one of the most common medical conditions she sees that causes weight gain is polycystic ovarian syndrome (PCOS), a condition that causes an imbalance of reproductive hormones that can cause infertility.

“I see a lot of people with this and it’s just very frustrating that they do the same as their friends and colleagues and just don’t get any weight loss result and then actually can get weight gain in a pattern that doesn’t really make sense because their bodies easily store fat and don’t let go of fat cells once they’re produced,” Dr. Lofton said.

“That’s a condition that really needs to be treated with dietary intervention and a lot of times, medication, for us to get significant weight loss results.”

Certain brain injuries, particularly injuries to the hypothalamus part of the brain, can also cause weight gain, Dr. Lofton said. The hypothalamus is the part of the brain that holds the appetite centers, but she said there are certain medications that can help appetite management.

Your family history or genetics could be causing you to gain weight, but it’s possible to overcome.

You don’t have to be the same as your family.
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Dr. Lofton said genetics can predispose people to gaining weight or to have trouble losing weight, but those factors can be overcome, much like the other causes of weight gain.

“We think my mom was heavy, my dad’s heavy, I’m just destined, there’s nothing I can do,” Dr. Lofton said. “It’s also about prevention when we’re younger before we reach overweight, making sure our lifestyle is as active as it can be. Environment can make all the difference.”

As you get older, your body is more prone to lose muscle mass and store fat.

Your metabolism and body changes as you get older.
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Patients in their 50s, 60s, and older often ask Dr. Lofton why their weight-loss practices from their younger years don’t work anymore.

“Your metabolism slows about 2% or so every couple of years, so it just gets harder to lose weight as you get older,” Dr. Lofton said. “What we can do to try to prevent that is continue muscle-building activity.”

“We lose muscle mass as we get older if we don’t actively try to recruit muscle and get stronger,” she continued. “And our hormones change and things like that, but again, that can be overcome. I have 85-year-old, 90-year-old people losing weight with diet and exercise, it’s just finding what works for you.”

Stress triggers your brain to crave comfort foods and stabilizes your fat cells.

Stress can lead to eating unhealthy food.
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According to Dr. Lofton, our bodies process stress with a fight or flight response.

“I liken that to we’re being chased by a bear,” she said. “Your body doesn’t focus on losing weight, it actually makes you prepare for the run or the fight.

Chronic stress, like for an accountant during tax season or a college student during finals, is worse. It can cause brain trauma that leads us to crave comfort foods.

“The stress can make our fat cells a little more stable, but it’s more likely that we’re just taking in more calories during that time,” she said.

Sleep deprivation gives you more opportunity to eat more and also triggers stress hormones.

Sleep deprivation can lead to more fat storage.
Paramount Pictures

When you aren’t sleeping, your body also processes that as stress, Dr. Lofton said.

“If you’re not sleeping at least seven hours for an adult, the body does not properly get the hormonal response about how much fat stores you have,” she said. “So, in order to preserve itself, the body … says, the person’s not sleeping enough, there must be a stressful event going on, like a famine or some kind of a predator, so let me make more fat stores and let me increase hunger.”

“That’s one of those evolutionary things,” she continued. “And the other thing is, the longer you stay awake, you’re inevitably going to get hungry again and then you have more opportunity to eat.”

If you exercise enough, your body could produce enough muscles to the point that you’re gaining muscle mass — and therefore, weight.

Gaining muscle can make you gain more weight overall.
Bojan Milinkov/Shutterstock

As you exercise, you burn fat and build muscle. If you’re gaining weight but have a good exercise routine and a healthy diet, it’s possible the weight is muscle mass, especially because muscles are heavier than fat.

“I could have two people of the same weight, one carrying more muscle mass and one carrying more fat mass,” Dr. Lofton said. “The first one with more muscle mass is more metabolically active. [He or she] uses up a lot of energy very quickly, it’s going to burn calories more quickly than someone who has that same, let’s say 150 pounds, of mostly fat.”

“Building muscle can help us, in the long term, lose fat. Even if one’s weight stays the same.”

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